The future fight against fat

Clinical trials will soon be under way for a nasal spray, developed by Compellis Pharmaceuticals in Somerville, MA, that blunts your sense of smell and taste, making food less appealing. In animal studies, rats gained 25% less weight after sniffing the drug; FDA approval is expected by 2010.

Scientists at Imperial College London have developed an appetite-suppressing compound that may be injected into foods and on the market within 5 to 8 years. It contains pancreatic polypeptide--a natural hormone that triggers fullness.

The Maestro, an implantable device being codeveloped by doctors at the Mayo Clinic in Rochester, MN, sends electric pulses to the abdomen that stop food-churning contractions so users feel satiated after eating less.

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