Facts about DHEA and Cortisol

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Facts about DHEA and Cortisol

- Bone density increases with DHEA levels

- DHEA is reduced in diabetics with high blood sugar

- Exercise and transcendental meditation increase DHEA

- Women with Alzheimer's disease have low DHEA levels in relation to cortisol

- DHEA protects the memory area of the brain affected by Alzheimer's disease from oxidative stress

- In one study, DHEA slashed a man's risk of heart disease in half, and his risk of mortality from all causes by 36%

- DHEA levels during various life stages: While human fetuses have high amounts of DHEA, babies and children have virtually none. DHEA reaches its peak in the 20s, and declines with old age. Older people have virtually no DHEA.

- Humans, chimpanzees and apes are the only known animals whose adrenals secrete large amounts of DHEA. Rodents rely on their sex organs for the hormone.

Barrett-Conner E, et al. 1986. A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. NEJM 315:1519-24.

Bastianetto S, et al. 1999. Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Mol Brain Res 66:35-41.

Glaser JL, et al. 1992. Elevated serum dehydroepiandrosterone sulfate levels in practitioners of Transcendental Meditation (TM) and TM-Sidhi programs. J Behav Med 15:327-41.

Hornsby PJ. Current challenges for DHEA research. In Dehydroepiandrosterone (DHEA) and aging. FL Bellino, et al., eds. Ann NY Acad Sci 774:xiii.

Johnson LG, et al. 1997. Effects of estrogen replacement therapy on dehydroepiandrosterone, dehydroepiandrosterone sulfate, and cortisol responses to exercise in postmenopausal women [published erratum appears in Fertil Steril 1998, 69:606]. Fertil Steril 68:836-43.

Leblhuber F, et al. 1993. Age and sex differences of dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels in normal controls and Alzheimer's disease (AD). Psychopharmacology:

Wild RA., et al. 1987. Declining adrenal androgens: an association with bone loss in aging women. Proc Soc Exp biol Med 186:355-60.

Yamaguchi Y, et al. 1998. Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia. Clin Endocrinol 49:377-83.

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