Perillyl Alcohol

Perillyl Alcohol

"In an article in Cancer Letters, perillyl alcohol was shown to reduce the growth of pancreatic tumors injected into hamsters to less than half that of controls. Moreover, 16% of pancreatic tumors treated with perillyl alcohol completely regressed, whereas no control tumors regressed (Stark et al. 1995).

Perillyl alcohol and perillic acid are metabolites of limonene. Limonene is only a weak inhibitor of the isoprenylation enzymes of Ras and other proteins, whereas perillyl alcohol and perillic acid are more potent inhibitors (Hardcastle et al. 1999)."

See: http://cancer.lef.org/pancreatic-3.html


FRAGRANT FACTS
- Orange and Lavender oils may be anti-cancer

- Orange oil, an orange extract, contains limonene. Lavender oil, (from Lavender flowers) contains a similar chemical - perillyl alcohol.

Both have anti-cancer activity. They help to break down carcinogens. This causes inhibition of cancer in animals (Carcinogenisis 1988;9:331-2) and inhibition of human breast cancer cells when transplanted into mice (Science News 1992;143:421). Of the two, perillyl alcohol appears more potent. Preliminary experiments to explore their effects in humans have recently begun.

Orange and Lavender oils can be found amongst "essential oils" in health food stores. If you're interested in trying these substances, be careful - essential oils are very strong. Try a drop - not a spoonful.

-- Health & Nutrition, a monthly newsletter

- Sperm Guided by The Smell of Egg's Sweet Perfume

The molecules the nose uses to pick up the scent of cologne have also been found on sperm, suggesting a microscopic courtship takes place in which sperm make their way by following the sweet perfume of human eggs.
The startling discovery suggests that a drug that blocks the sperm's ability to sense that enticing aroma could be used as a male contraceptive, said Dr. Robert J. Lefkowitz of Duke University. "Such a drug could be the ideal contraceptive," Lefkowitz said. It would likely have few side effects, because the smell receptors on which it would acts exist nowhere else in the body except on sperm and in the nose," he said.

He said the discovery of the sperm's smell receptors is one example of how basic research on receptors and their signaling systems can lead to unexpected applications.

Lefkowitz has spent decades studying cell receptors and the signaling molecules called G proteins that carry information inside cells. When he began the work, he had only faith to go on that something useful would eventually come of it, he said.

It was known that fish sperm, for example, must have some way to find eggs. "They definitely need a way of sensing, by chemicals, how they know where to go. They eject their sperm in billions of gallons of sea water," Dr. Gabriele Ronnett said.

The situation with mammals was unknown, so Ronnett looked. She found the receptors on the sperm of laboratory rats, and then found similar smell receptors in human tissue.

To make a contraceptive, "the idea would be to develop a drug which binds to those receptors," Lefkowitz said. The class of drugs called beta blockers -- among the most widely used treatments for hart disease -- work exactly that way.
-- The New Mexican, Nov, 8, 1995

- No, it was neither the Germans nor the Irish but the ancient Egyptians who built altars to the cabbage.
- In response to a client's query, all I can find in our Love and War man's file labeled "Lowest Divorce Rate" is this item: "The fruit fly lives only 24 hours."

- VIETNAM "OFFICIALLY" SOURCE FOR U.S. ESSENTIAL OILS

As practically the only producer besides China, Vietnam could have a corner on supplying the US with Cassia, Sassafras, and Ylang Ylang oils now that diplomatic relations have been restored. The US has probably been dealing with Vietnamese oils all along, just under different names.

"Essential oils are hard to identify," says one dealer. "We have probably already seen their contributions at some point. Vietnamese Lemongrass routed to Burma, Citronella from Vietnam shipped to India, or Cassia could have gone to China. At those stops they were re-stamped and then sent to the US. Only the US had an embargo against Vietnam, everyone else has been dealing with them."

In the long run, Vietnam's entry into the market will probably have a modest impact. Consultants are saying that there could be a 10-, 20-, or 50-percent drop per pound for all essential oils over the next 5 to 10 years, but, compared to the wide fluctuations in price that essential oils normally endure, this is almost nothing. The one area where Vietnam may flourish is in the subtleties of taste. If it can produce an oil that is superior to, say, Chinese Cassia, it may find Coca-Cola looking at its products.

-- From Market Report by Peter Landes HerbalGram Number 35 [Chemical Marketing Reporter, July 7, 1995]
- You, too, may find hard to accept this notion that women who have no children are generally happier than mothers. And that childless wives are more satisfied with their marriages than are mothers. But such were the conclusions drawn by a national magazine's editors after they surveyed 30,000 women.

- People invariably lose weight at high altitudes. Tissues break down, but don't build up, for reasons not yet fully understood. Or so contends one medical specialist. Interesting. But the view of only one specialist is not conclusive, I think. Check your sources in Denver on this one.
Article copyright The Herbal Rose Report.

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