Triphala

Triphala

The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality inmice exposed to 7–12 Gray (Gy) of?-irradiation. Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness whencompared with the non-drug double distilled water treated irradiated controls (DDW). Triphala provided protectionagainst both gastrointestinal and hemopoetic death. However, animals of both the TE + irradiation andDDW + irradiation groups did not survive up to 30 days post-irradiation beyond 11 Gy irradiation. The LD50/30was found to be 8.6 Gy for the DDW + irradiation group and 9.9 Gy for TE + irradiation group. The administrationof triphala resulted in an increase in the radiation tolerance by 1.4 Gy, and the dose reduction factorwas found to be 1.15. To understand the mechanism of action of triphala, the free radical scavengingactivity of the drug was evaluated. Triphala was found to scavenge·OH, O·? 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS)·+ and NO· radicals in a dose dependent manner.

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