Leukemia Treated With Vitamin Analogs

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Leukemia Treated With Vitamin Analogs

1. Vitamin D3 encased in a liposome drug blocked proliferation and induced differentiation in myelomonocytic leukemia cells. The liposome drug was specific to myeloid cells, enabling high concentrations of vitamin D3 to be delivered.

British Journal of Hematology, 1997, Vol 98, Iss 1, pp 186-194, M Frankenberger, B Hofmann, B Emmerich, C Nerl, RA Schwendener, HWL, Ziegler-Heibrock

2. The addition of vitamin D3 analog drugs to the standard immune boosting drug granulocyte-macrophage colony-stimulating factor (GM-CSF) produced an enhancement in leukemic cell differentiation and greater inhibition of leukemic cell proliferation, indicating potential therapeutic benefit to the combination of these drugs in the treatment of various leukemia.

Leukemia, 1997, Vol 11, Iss 7, pp 1017-1025, SY James, MA Williams, SM Kelsey, AC Newland, KW Colston,

3. Excess vitamin D3 can be produced by certain immune cells to cause hypercalcemia. Gamma interferon was shown to inhibit abnormal synthesis of vitamin D in immune cells, thus reducing the risk of hypercalcemia in the leukemia patient taking vitamin D.

Journal of Clinical Endocrinology and Metabolism, 1997, Vol 82, Iss 7, pp 2222-2232, J Klein, SS Chatterjee

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